Palisaded Neutrophilic and Granulomatous Dermatitis-Like Reaction Associated with Wilms Tumor 1 Protein-Derived Peptide Vaccine: A Case and Review of the Literature

Authors

  • Lucy Rose The Ohio State University College of Medicine
  • Michela Paradiso The Ohio State University Wexner Medical Center, Department of Dermatology
  • Jose Plaza The Ohio State University Wexner Medical Center, Department of Dermatology & Department of Pathology
  • David M. O'Malley The Ohio State University and the James Cancer Center, Division of Gynecologic Oncology
  • Brittany Dulmage The Ohio State University Wexner Medical Center, Department of Dermatology

DOI:

https://doi.org/10.18061/ad.v2i1.9639

Keywords:

Palisaded neutrophilic and granulomatous disease, experimental vaccine, cancer vaccine

Abstract

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an inflammatory cutaneous reaction that is associated with underlying autoimmune diseases. In rare cases, PNGD has been attributed to systemic medications. Here we report one case of a cutaneous injection-site reaction that occurred after intradermal administration of an experimental Wilms Tumor 1 (WT1) protein-derived peptide vaccine in a woman being treated for recurrent ovarian cancer. This is the first reported case of a PNGD-like reaction associated with immunotherapy injections. In this article, we discuss this case and summarize the literature related to the diagnosis and management of PNGD, as well as other injection site reactions related to immunotherapies and experimental vaccines.

Cover for Vol. 2, No. 1 of Academic Dermatology

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Published

2024-04-08

How to Cite

Rose, L., Paradiso, M., Plaza, J., O’Malley, D. M., & Dulmage, B. (2024). Palisaded Neutrophilic and Granulomatous Dermatitis-Like Reaction Associated with Wilms Tumor 1 Protein-Derived Peptide Vaccine: A Case and Review of the Literature. cademic ermatology, 2(1), 1–6. https://doi.org/10.18061/ad.v2i1.9639

Issue

Vol. 2 No. 1 (2024): Academic Dermatology Expands

Section

Articles

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Copyright (c) 2024 Lucy Rose, Michela Paradiso, Jose Plaza, David M. O'Malley, Brittany Dulmage

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