Primary Cutaneous Marginal Zone Lymphoma: A Comprehensive Review

Authors

  • Jordyn Puccio The Ohio State University College of Medicine https://orcid.org/0009-0009-8642-1204
  • Teja Mallela The Ohio State University College of Medicine https://orcid.org/0009-0006-9876-2629
  • Nassim Idouraine The Ohio State University College of Medicine
  • Matthew Gallardo The Ohio State University College of Medicine https://orcid.org/0000-0002-2197-933X
  • Catherine Chung Department of Dermatology, The Ohio State University Wexner Medical Center; Department of Pathology, The Ohio State University Wexner Medical Center
  • Kirsten Johnson Department of Dermatology, The Ohio State University Wexner Medical Center https://orcid.org/0000-0003-2388-0621
  • Brittany Dulmage Department of Dermatology, The Ohio State University Wexner Medical Center https://orcid.org/0000-0003-3043-8903

DOI:

https://doi.org/10.18061/ad.v3i1.9994

Keywords:

oncodermatology, oncology, treatment options, clinical research

Abstract

Primary cutaneous marginal zone lymphoma (PCMZL) represents a subset of primary cutaneous B-cell lymphomas (PCBCL) and an even smaller subset of all cutaneous lymphomas. Due to PCMZL’s indolent nature, the differentiation between PCMZL and other more aggressive PCBCLs can be challenging and result in the delay of diagnosis and treatment. The diagnosis of PCMZL requires clinical evaluation combined with immunohistochemical analysis to differentiate it from other lymphoma and non-lymphoma pathologies. The condition’s wide range of treatment options, including novel therapies, have led to various outcomes for patients diagnosed with PCMZL.  This comprehensive review article emphasizes the clinical presentation and the methods of diagnosis, including appropriate pathologic evaluation, differentiating factors from other non-PCMZL conditions, and current treatment options for PCMZL.

Photograph of a patient with scurvy.

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Published

2025-07-18

How to Cite

Puccio, J., Mallela, T., Idouraine, N., Gallardo, M., Chung, C., Johnson, K., & Dulmage, B. (2025). Primary Cutaneous Marginal Zone Lymphoma: A Comprehensive Review. cademic ermatology, 3(1), 1–14. https://doi.org/10.18061/ad.v3i1.9994

Issue

Vol. 3 No. 1 (2025)

Section

Reviews

License

Copyright (c) 2025 Jordyn Puccio, Teja Mallela, Nassim Idouraine, Matthew Gallardo, Catherine Chung, Kirsten Johnson, Brittany Dulmage

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